SKINDERMA Hyaluronidase Ampoules – Fat Reduction & Diffusing Mesotherapy 20 x 5ml

SKINDERMA Hyaluronidase is a professional mesotherapy enzyme solution that depolymerises glycosaminoglycans, targets water retention, and reduces localized adiposity — while also acting as a powerful spreading factor to enhance the absorption and diffusion of co-administered active ingredients.

Key Benefits

• Breaks down glycosaminoglycans for improved tissue permeability
• Reduces localised water retention and puffiness
• Targets fat deposits and reduces adiposity
• Enhances the diffusion and effectiveness of co-administered actives
• Supports body contouring and anti-cellulite protocols

Active Ingredient

• Hyaluronidase — a naturally occurring enzyme that catalyzes the depolymerization of hyaluronic acid and other glycosaminoglycans in the extracellular matrix, temporarily increasing tissue permeability. In aesthetic mesotherapy, this dual action makes Hyaluronidase uniquely valuable: first, as a fat and cellulite treatment — by breaking down the glycosaminoglycan-rich matrix that traps water and contributes to the structural hardening seen in cellulite and localized adiposity, improving drainage and tissue remodeling; and second, as a spreading factor (diffusion enhancer) — by temporarily opening the extracellular matrix, Hyaluronidase dramatically increases the absorption zone and bioavailability of co-administered actives such as L-Carnitine, Caffeine, and lipolytic cocktails. It is also widely used in aesthetic medicine for the correction and dissolution of hyaluronic acid fillers.

Treatment Area: Face & Neck; Body
Recommended For: Fat disorders, water retention, cellulite, lipolytic protocols, and filler correction
Presentation: 20 x 5ml ampoules

What is Hyaluronidase and how does it work in mesotherapy? Hyaluronidase is an enzyme that breaks down hyaluronic acid and glycosaminoglycans in the extracellular matrix, temporarily increasing tissue permeability. In mesotherapy, this serves two key functions: it reduces the glycosaminoglycan-rich matrix that contributes to water retention, cellulite, and localized adiposity; and it acts as a spreading factor that dramatically increases the diffusion and bioavailability of co-administered actives such as lipolytic cocktails, L-Carnitine, and Caffeine — making combined protocols significantly more effective.

Can Hyaluronidase be used to dissolve hyaluronic acid fillers? Yes — Hyaluronidase is the standard of care for hyaluronic acid filler correction and emergency dissolution in aesthetic medicine. Applied to or around a filler deposit, it rapidly breaks down the cross-linked hyaluronic acid network, reversing overfilling, correcting asymmetry, or addressing complications. This makes it an essential safety and correction tool for any clinic performing dermal filler treatments.

What conditions does Hyaluronidase address in body contouring? Hyaluronidase is recommended for localized water retention, cellulite (particularly fibrotic and edematous types), localized fat deposits, and as a diffusion enhancer in lipolytic mesotherapy protocols. Its ability to break down the structural glycosaminoglycan matrix makes it particularly effective for edematous cellulite where fluid accumulation and poor drainage are contributing factors.

Who is this product for? SKINDERMA Hyaluronidase is formulated for licensed aesthetic practitioners, dermatologists, and body contouring specialists using it in mesotherapy protocols for fat reduction, cellulite, water retention, and filler correction. 

Professional use only. Not intended to diagnose, treat, cure, or prevent any disease.