SKINDERMA Antiaging Combo – Multi-Active Collagen & Wrinkle Mesotherapy Cocktail 5 x 10ml

SKINDERMA Antiaging Combo is a comprehensive professional microneedling mesotherapy cocktail combining five powerful actives to promote collagen production, minimize wrinkles, deeply moisturize, firm the skin, and inhibit facial muscle contractions — delivering a complete multi-pathway anti-aging treatment in a single protocol. Each ingredient targets a distinct mechanism of skin aging, and together they address the full spectrum of facial aging concerns simultaneously.

Key Benefits

• Promotes collagen production and deep skin rejuvenation
• Minimizes fine lines, wrinkles, and expression lines
• Deeply moisturizes and restores skin volume and plumpness
• Firms and lifts sagging skin on face and neck
• Inhibits facial muscle contractions to prevent new expression lines
• Antioxidant and barrier-repair protection for long-term skin health

Active Ingredients

• Panthenol (Provitamin B5) — the alcohol analog of pantothenic acid (Vitamin B5) and a direct precursor to Coenzyme A, which is essential for fatty acid synthesis and cellular energy metabolism. In skin biology, Panthenol is a highly effective humectant that attracts and retains moisture in the dermis, and a proven wound-healing and barrier-repair active — stimulating keratinocyte proliferation, accelerating epidermal repair, and supporting fibroblast differentiation and collagen synthesis. In mesotherapy protocols, Panthenol enhances the skin’s structural repair capacity and contributes to the formula’s overall anti-aging and skin renewal effect.
• DMAE (Dimethylaminoethanol) — a naturally occurring choline precursor that increases acetylcholine availability in the dermis, enhancing the tone of underlying facial musculature for a visible lifting and firming effect on lax skin. DMAE also stabilizes cell membrane phospholipid bilayers, increasing membrane rigidity and protecting against oxidative damage — contributing both a mechanical firming action and antioxidant protection to the formula.
• Organic Silicium (Methylsilanol Mannuronate) — a bioavailable marine-derived form of silicon that plays a structural role in the extracellular matrix by stimulating fibroblast activity and reinforcing collagen and elastin cross-linking. Silicium is a cofactor in the hydroxylation of proline and lysine residues in collagen — the key step in forming stable, cross-linked collagen fibrils. As the skin’s Silicium content declines with age, supplementation via mesotherapy directly supports the structural renewal of the dermis, improving skin density, firmness, and elasticity.
• Asian Centella (Centella asiatica Extract) — standardized for its four active triterpenoids (asiaticoside, madecassoside, asiatic acid, madecassic acid), which collectively stimulate fibroblast proliferation and collagen type I and III synthesis, inhibit collagenase-mediated matrix degradation, strengthen capillary walls, and reduce inflammation. Centella provides the formula’s primary collagen-stimulating and microvascular support action, complementing the structural reinforcement provided by Silicium.
• Sodium Hyaluronate — the sodium salt of hyaluronic acid, with an extraordinary capacity to bind up to 1,000 times its weight in water. In mesotherapy protocols, it restores deep dermal hydration, replenishes lost skin volume, and creates the optimal hydrated environment for fibroblast activity and collagen synthesis — amplifying the regenerative effect of the formula’s other actives while providing immediate visible plumping and wrinkle-filling results.

Treatment Area: Face & Neck
Recommended For: Expression lines, eye contour, sagging skin, fine lines, and wrinkles
Presentation: 5 x 10ml vials

What makes SKINDERMA Antiaging Combo a complete anti-aging protocol in one vial? Antiaging Combo targets five distinct mechanisms of skin aging simultaneously: Sodium Hyaluronate restores dermal hydration and volume; DMAE lifts and firms via acetylcholine-mediated muscle tone and membrane stabilization; Organic Silicium reinforces collagen and elastin cross-linking; Centella asiatica stimulates fibroblast collagen synthesis and microvascular integrity; and Panthenol supports epidermal repair and barrier function. Together, they address hydration loss, structural laxity, muscle-driven expression lines, collagen depletion, and barrier impairment — the five primary drivers of visible facial aging.

How does Organic Silicium contribute to collagen formation? Silicon is a structural cofactor in collagen biosynthesis — specifically in the hydroxylation of proline and lysine residues, which is required to form stable cross-linked collagen fibrils. Skin Silicium content declines significantly with age, contributing to reduced collagen density and skin laxity. Methylsilanol Mannuronate (Organic Silicium) delivers bioavailable silicon directly to the dermis via mesotherapy, supporting the enzymatic steps in collagen fiber formation and the cross-linking of elastin — improving skin density, firmness, and structural resilience over a course of treatments.

What skin concerns does Antiaging Combo address? This formula is recommended for mature skin with multiple concurrent aging concerns — including fine lines and deep wrinkles, sagging and lax skin, loss of volume and hydration, dull complexion, expression lines, and impaired skin barrier function. Its multi-pathway approach makes it ideal as a comprehensive rejuvenation protocol or as a foundational treatment combined with targeted actives for specific concerns.

Who is this product for? SKINDERMA Antiaging Combo is formulated for licensed aesthetic practitioners, dermatologists, and skin clinics performing professional multi-active anti-aging mesotherapy and microneedling protocols. 

Professional use only. Not intended to diagnose, treat, cure, or prevent any disease.